Vaccines are responsible for some of the greatest public health triumphs ever, including the eradication of naturally occurring smallpox and the almost complete removal of polio from the planet. It is a cost-effective healthcare intervention with significant economic impact.
Recombinant protein vaccines
Recombinant protein vaccines are subunit vaccines that utilise only a small part of the pathogen and elicit an immune response against them1.
Advantages2,3:
Antigen has a well-defined composition
No risk of pathogenicity
Synthesis and purification can be scaled up in a cost-effective manner
Almost negligible side effects
Safer than live-attenuated and inactivated killed vaccines
Recombinant Platform Technology
Conjugate vaccines
Conjugate vaccines are composed of pathogen-specific capsular polysaccharides (CPS) conjugated to an immunostimulatory protein carrier4.
Advantages5:
Enhance the poor immunologic responses
Reduce asymptomatic carriage of the bacteria
Safe and immunogenic in young infants
Induces long-term memory
*x – different combinations of serotype based on prevalence
*x – different combinations of serotype based on prevalence
1. Matić Z, Šantak M. Current view on novel vaccine technologies to combat human infectious diseases.Appl Microbiol Biotechnol. 2022;106(1):25-56. doi:10.1007/s00253-021-11713-0
2. Bill RM. Recombinant protein subunit vaccine synthesis in microbes: a role for yeast?. J PharmPharmacol. 2015;67(3):319-328. doi:10.1111/jphp.12353.
3. Wang M, Jiang S, Wang Y. Recent advances in the production of recombinant subunit vaccines in Pichia pastoris. Bioengineered. 2016;7(3):155-165. doi:10.1080/21655979.2016.1191707.
4. Stark JC, Jaroentomeechai T, Moeller TD, et al. On-demand biomanufacturing of protective conjugate vaccines. Sci Adv. 2021;7(6):eabe9444. Published 2021 Feb 3. doi:10.1126/sciadv.abe9444
5. Kumraj G, Pathak S, Shah S, et al. Capacity Building for Vaccine Manufacturing Across Developing Countries: The Way Forward. Hum Vaccin Immunother. 2022;18(1):2020529. doi:10.1080/21645515.2021.2020529
